Making sense of scattering: Seeing microstructure through shear waves - Laboratoire de bio-ingénierie cardiovasculaire pour la thérapie et pour l'imagerie médicale-LVTS
Article Dans Une Revue Science Advances Année : 2024

Making sense of scattering: Seeing microstructure through shear waves

Giacomo Annio
Sverre Holm
Gabrielle Mangin
Jake Penney
Raphael Bacquët
  • Fonction : Auteur
Rami Mustapha
Omar Darwish
  • Fonction : Auteur
Anna Sophie Wittgenstein
  • Fonction : Auteur
Katharina Schregel
Valérie Vilgrain
Valérie Paradis
  • Fonction : Auteur
Knut Sølna
  • Fonction : Auteur
David Alexander Nordsletten

Résumé

The physics of shear waves traveling through matter carries fundamental insights into its structure, for instance, quantifying stiffness for disease characterization. However, the origin of shear wave attenuation in tissue is currently not properly understood. Attenuation is caused by two phenomena: absorption due to energy dissipation and scattering on structures such as vessels fundamentally tied to the material’s microstructure. Here, we present a scattering theory in conjunction with magnetic resonance imaging, which enables the unraveling of a material’s innate constitutive and scattering characteristics. By overcoming a three-order-of-magnitude scale difference between wavelength and average intervessel distance, we provide noninvasively a macroscopic measure of vascular architecture. The validity of the theory is demonstrated through simulations, phantoms, in vivo mice, and human experiments and compared against histology as gold standard. Our approach expands the field of imaging by using the dispersion properties of shear waves as macroscopic observable proxies for deciphering the underlying ultrastructures.
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hal-04800714 , version 1 (24-11-2024)

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Giacomo Annio, Sverre Holm, Gabrielle Mangin, Jake Penney, Raphael Bacquët, et al.. Making sense of scattering: Seeing microstructure through shear waves. Science Advances , 2024, 10 (31), ⟨10.1126/sciadv.adp3363⟩. ⟨hal-04800714⟩

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