Mice Autophagy KNOCKOUT MICE DMSXL mice Brain Myotonic dystrophy type 1 Exercise Gene Therapy Cell model Therapy Central nervous system Dystrophie Myotonique Glial cells Alternative splicing Gene therapy Humans PacBio Gene editing Heart failure Cytoskeleton Animals Oligodendrocyte CONGENITAL MYATHENIC SYNDROME Maximal force Trinucleotide Repeat Expansion Thérapie génique Transgenic mouse model Myotonic Dystrophy type 1 Antisense oligonucleotides ARN Cardiac muscle Centronuclear myopathy Mouse models Desmin In vivo Quantitative microdialysis PCR CRISPR/Cas9 Diaphragm MBNL GABA Cell culture model CTG repeats Skeletal muscle Exercice Myotonic Dystrophy Type 1 Cell penetrating peptide Transgenic mouse Astrocyte Myostatin Intermediate filament Expression Heart Glucocorticoids Endurance training Astrocytes DM1 BIOLOGIE MOLECULAIRE Glucocorticoid-receptor GSK3␤ Myotonic Dystrophy RNA interference Dystrophin CMS Glutamate Acute coronary syndrome Hypoxia Myotonic dystrophy mouse models Duchenne muscular dystrophy Motoneuron Aging Myotonic dystrophy Dystrophie myotonique ACETYLCHOLINESTERASE RNA biology Acetylcholinesterase deficiency Dynamin 2 Muscle Genotype phenotype correlation Fibrosis AAV Acetylcholinesterase knockout mouse Brain dysfunction Antisense oligonucleotide CTG repeat contractions Neuron DMPK Oligodendrocytes Transcriptomics Long read sequencing Knockout Muscular dystrophy Trinucleotide repeat expansion Myelin Male RNA splicing CRISPRi Dilated cardiomyopathy CTG repeat instability Mouse model