Heparin-like synthetic polymers, named RGTAs, mimic biological effects of heparin in vitro. - Université Sorbonne Paris Nord Accéder directement au contenu
Article Dans Une Revue Journal of Biomedical Materials Research Part A Année : 2006

Heparin-like synthetic polymers, named RGTAs, mimic biological effects of heparin in vitro.

Résumé

A family of biopolymers engineered to protect and stabilize heparin binding growth factors (HBGFs) show remarkable properties as wound healing agents in several in vivo tissue repair models to the extend that damaged tissues would recover almost its initial aspect and properties. These polymers where named RGTA for regenerating agents and proposed to act in vivo by enhancing the bioavailability of HBGFs at the site of the injury. To provide support for this hypothesis, we studied interaction of RGTA with FGF-2, taken as the paradigm of HBGFs, and its high- and low-affinity receptors as well as its ability to inhibit heparanase activity. We show that RGTA is comparable to heparin as it favors FGF-2 binding to FGFR-1 and FGF-2 dimerization and potentiates FGF-2-induced mitogenic activity. Furthermore, we show that RGTA inhibits the release of FGF-2 from its extracellular matrix storage sites by heparanase. Our data provide new evidence to support that RGTA may act in vivo both by enhancing HBGF activity and preserving HBGF availability by protecting the matrix low affinity heparan sulfates from rapid heparanase degradation
Fichier non déposé

Dates et versions

hal-00109644 , version 1 (25-10-2006)

Identifiants

  • HAL Id : hal-00109644 , version 1
  • PUBMED : 16741978

Citer

V. Rouet, A. Meddahi-Pelle, Hq Miao, I. Vlodavsky, Jp Caruelle, et al.. Heparin-like synthetic polymers, named RGTAs, mimic biological effects of heparin in vitro.. Journal of Biomedical Materials Research Part A, 2006, pp.792-797. ⟨hal-00109644⟩
63 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More