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Article Dans Une Revue Synthesis: Journal of Synthetic Organic Chemistry Année : 2008

Iron-catalyzed alkenylation of Grignard reagents by enol phosphates

Résumé

Stereoselective preparation of trisubstituted olefins can be easily performed from an Z/E-mixture of enol phosphates by reacting only the E-isomer with a Grignard reagent in the presence of Fe(acac)(3). This procedure combines a kinetic differentiation and a stereoselective reaction. The coupling is very chemoselective in the presence of an alkyl chloride, an ester, a ketone or a nitrile.
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Dates et versions

hal-00462616 , version 1 (10-03-2010)

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Citer

G. Cahiez, O. Gager, V. Habiak. Iron-catalyzed alkenylation of Grignard reagents by enol phosphates. Synthesis: Journal of Synthetic Organic Chemistry, 2008, 16, pp.2636-2644. ⟨10.1055/s-2008-1067194⟩. ⟨hal-00462616⟩
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