Factors associated with non-AIDS-defining cancers and non HCV-liver related cancers in HIV/HCV-coinfected patients- ANRS-CO13 HEPAVIH cohort - Université Sorbonne Paris Nord Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2018

Factors associated with non-AIDS-defining cancers and non HCV-liver related cancers in HIV/HCV-coinfected patients- ANRS-CO13 HEPAVIH cohort

1 BPH - Bordeaux population health
2 UPD5 - Université Paris Descartes - Paris 5
3 Service d'Immuno-hématologie clinique [Hôpital Sainte Marguerite - APHM]
4 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
5 CHU Pitié-Salpêtrière [AP-HP]
6 iPLESP - Institut Pierre Louis d'Epidémiologie et de Santé Publique
7 SU FM - Sorbonne Université - Faculté de Médecine
8 SU - Sorbonne Université
9 Service des Maladies Infectieuses et Tropicales A [Bordeaux]
10 UB - Université de Bordeaux
11 CHU Bordeaux
12 Hôpital Pellegrin
13 CHU Tenon [AP-HP]
14 Service de médecine interne et maladies infectieuses [Bordeaux]
15 CHU Saint-Antoine [AP-HP]
16 Service d'infectiologie [CHU Nice]
17 CHU Toulouse - Centre Hospitalier Universitaire de Toulouse
18 Service des maladies infectieuses et tropicales
19 Service des maladies infectieuses et tropicales
20 Hôpital Avicenne [AP-HP]
21 CHU - Hôpital Archet 2 [Nice]
22 UNS UFR Médecine - Université Nice Sophia Antipolis - Faculté de Médecine
23 Service de maladies infectieuses et tropicales [Saint-Louis]
24 Service Maladies infectieuses et tropicales [CHU Toulouse]
25 UT3 - Université Toulouse III - Paul Sabatier
26 PHARMA-DEV - Pharmacochimie et Biologie pour le Développement
27 DILTEC - DILTEC - Didactique des langues, des textes et des cultures - EA 2288
28 Hôpital Henri Mondor
29 AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)
30 Hôpital Necker - Enfants Malades [AP-HP]
31 Centre Hospitalier Saint Jean de Perpignan
32 Service de Maladies Infectieuses et Tropicales [Hôpital de la Croix-Rousse - HCL]
33 Hôpital Foch [Suresnes]
34 Service de maladies infectieuses et tropicales [Nantes]
35 CIC Nantes - Centre d’Investigation Clinique de Nantes
36 Hôpital universitaire Robert Debré [Reims]
37 URCA - Université de Reims Champagne-Ardenne
38 CardioVir - Laboratoire de Virologie Médicale et Moléculaire - EA 4684
Mathieu Chalouni
Julie Chas
  • Fonction : Auteur
Karl Barange
  • Fonction : Auteur
  • PersonId : 906170
David Zucman
  • Fonction : Auteur
  • PersonId : 915371
Laure Esterle
Linda Wittkop

Résumé

Compared to the general population, HIV-infected patients are at higher risk of developing non-AIDS-defining cancers. Chronic HCV infection has also been associated with a higher risk than that of the general population of developing cancers other than hepatocarcinoma. Evaluation of the impact of HCV-related factors on non-AIDS-defining and non HCV-liver (NANL) related cancers among HIV/HCV co-infected patients are scarce. The aim of this study was to identify the impact of HIV/HCV clinical characteristics on NANL related cancers in a large cohort of HIV/HCV-coinfected patients followed from 2005 to 2017. Cox proportional hazards models with delayed entry were used to estimate factors associated with NANL related cancer. Among 1391 patients followed for a median of 5 years, 60 patients developed NANL related cancers, yielding an incidence rate of 8.9 per 1000 person-years (95% CI, [6.6-11.1]). By final multivariable analysis, after adjustment for sex, tobacco or alcohol consumption, baseline CD4 cell count and HCV sustained viral response (SVR), age and a longer duration since HIV diagnosis were independently associated with a higher risk of NANL related cancer (aHR for each additional year 1.10, 95% CI 1.06-1.14, p<0.0001 and 1.06, 95% CI 1.01-1.11, p = 0.02, respectively). Duration of HCV infection, cirrhosis, HCV viral load, genotype and SVR were not associated with the occurrence of NANL related cancer. Among HIV/HCV-coinfected patients, age and the duration of HIV infection were the only characteristics found to be associated with the occurrence of NANL related cancer. In contrast, no association was observed with any HCV-related variables.
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Dates et versions

hal-01974344 , version 1 (08-01-2019)

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Citer

Oumar Billa, Mathieu Chalouni, Dominique Salmon, Isabelle Poizot-Martin, Camille Gilbert, et al.. Factors associated with non-AIDS-defining cancers and non HCV-liver related cancers in HIV/HCV-coinfected patients- ANRS-CO13 HEPAVIH cohort. PLoS ONE, 2018, 13 (12), pp.e0208657. ⟨10.1371/journal.pone.0208657⟩. ⟨hal-01974344⟩
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