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Article Dans Une Revue Nephrology Dialysis Transplantation Année : 2019

The expanding roles of microRNAs in kidney pathophysiology

Résumé

MicroRNAs (miRNAs) are short single-stranded RNAs that control gene expression through base pairing with regions within the 30-untranslated region of target mRNAs. These small non-coding RNAs are now increasingly known to be involved in kidney physiopathology. In this review we will describe how miRNAs were in recent years implicated in cellular and animal models of kidney disease but also in chronic kidney disease, haemodialysed and grafted patients, acute kidney injury patients and so on. At the moment miRNAs are considered as potential biomarkers in nephrology, but larger cohorts as well as the standardization of methods of measurement will be needed to confirm their usefulness. It will further be of the ut- most importance to select specific tissues and biofluids to make miRNAs appropriate in day-to-day clinical practice. In addition, up- or down-regulating miRNAs that were described as deregulated in kidney diseases may represent innovative therapeutic methods to cure these disorders. We will enumerate in this review the most recent methods that can be used to deliver miRNAs in a specific and suitable way in kidney and other organs damaged by kidney failure, such as the cardiovascular system.

Dates et versions

hal-02061515 , version 1 (08-03-2019)

Identifiants

Citer

Valérie Metzinger-Le Meuth, Ophélie Fourdinier, Nathalie Charnaux, Ziad Massy, Laurent Metzinger. The expanding roles of microRNAs in kidney pathophysiology. Nephrology Dialysis Transplantation, 2019, 34 (1), pp.7-15. ⟨10.1093/ndt/gfy140⟩. ⟨hal-02061515⟩
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