“Real life” use of raltegravir during pregnancy in France: The Coferal-IMEA048 cohort study - Université Sorbonne Paris Nord Accéder directement au contenu
Article Dans Une Revue PLoS ONE Année : 2019

“Real life” use of raltegravir during pregnancy in France: The Coferal-IMEA048 cohort study

Odile Launay
Ana Canestri
  • Fonction : Auteur
Dominique Trias
  • Fonction : Auteur

Résumé

INTRODUCTION: Limited "real life" data on raltegravir (RAL) use during pregnancy are available. Thus, we aimed at describing effectiveness and safety of RAL-based combined antiretroviral therapy (cART) in this setting. METHODS: HIV-1-infected women receiving RAL during pregnancy between 2008 and 2014 in ten French centers were retrospectively analysed for: (1) proportion of women receiving RAL anytime during pregnancy who achieved a plasma HIV-RNA (pVL) < 50 copies/mL at delivery, and (2) description of demographics, immuno-virological parameters and safety in women and new-borns. RESULTS: We included 94 women (median age, 33 years) of which 85% originated from Sub-Saharan Africa and 16% did not have regular health insurance coverage. Sixteen women were cART-naïve (median HIV diagnosis at 30 weeks of gestation), whereas 78 were already on cART before pregnancy (40% with pVL < 50 copies/mL). RAL was initiated before pregnancy (n = 33), during the second trimester (n = 11) and the third trimester of pregnancy (n = 50). No RAL discontinuations due to adverse events were observed. Overall, at the time of delivery, pVL was < 50 copies/mL in 70% and < 400 copies/mL in 84% of women. Specifically, pVL at delivery was < 50 copies/mL in 82%, 55% and 56% of cases when RAL was started before pregnancy, during the second or third trimester of pregnancy, respectively. Median term was 38 weeks of gestation, no defect was reported and all new-borns were HIV non-infected at Month 6. CONCLUSIONS: RAL appears safe and effective in this "real-life" study. No defect and no HIV transmission was reported in new-borns.
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hal-02120969 , version 1 (06-05-2019)

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Pierre Gantner, Babacar Sylla, Laurence Morand-Joubert, Pierre Frange, Karine Lacombe, et al.. “Real life” use of raltegravir during pregnancy in France: The Coferal-IMEA048 cohort study. PLoS ONE, 2019, 14 (4), pp.e0216010. ⟨10.1371/journal.pone.0216010⟩. ⟨hal-02120969⟩
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