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Article Dans Une Revue Archives of Internal Medicine -New Series- Année : 2012

B Vitamin and/or ω-3 Fatty Acid Supplementation and Cancer

Résumé

Background: To advance knowledge about the cancer-chemopreventive potential of individual nutrients, we investigated the effects of B vitamin and/or omega-3 fatty acid supplements on cancer outcomes among survivors of cardiovascular disease. Methods: This was an ancillary study of the Supplementation With Folate, Vitamins B-6 and B-12 and/or Omega-3 Fatty Acids (SU.FOL.OM3) secondary prevention trial (2003-2009). In all, 2501 individuals aged 45 to 80 years were randomized in a 2 x 2 factorial design to one of the following 4 daily supplementation groups: (1) 5-methyltetrahydrofolate (0.56 mg), pyridoxine hydrochloride (vitamin B-6;3 mg) and cyanocobalamin (vitamin B-12;0.02 mg); (2) eicosapentaenoic and docosahexaenoic acid (600 mg) in a 2: 1 ratio; (3) B vitamins and omega-3 fatty acids; or (4) placebo. Overall and sex-specific hazard ratios (HRs) and 95% Cls regarding the cancer outcomes were estimated with Cox proportional hazards models. Results: After 5 years of supplementation, incident cancer was validated in 7.0% of the sample (145 events in men and 29 in women), and death from cancer occurred in 2.3% of the sample. There was no association between cancer outcomes and supplementation with B vitamins (HR, 1.15 [95% CI, 0.85-1.55]) and/or omega-3 fatty acids (HR, 1.17 [95% CI, 0.87-1.58]). There was a statistically significant interaction of treatment by sex, with no effect of treatment on cancer risk among men and increased cancer risk among women for omega-3 fatty acid supplementation (HR, 3.02 [95% CI, 1.33-6.89]). Conclusion: We found no beneficial effects of supplementation with relatively low doses of B vitamins and/ or omega-3 fatty acids on cancer outcomes in individuals with prior cardiovascular disease.

Dates et versions

hal-02419963 , version 1 (19-12-2019)

Identifiants

Citer

Valentina A. Andreeva, Mathilde Touvier, Emmanuelle Kesse-Guyot, Chantal Julia, Pilar Galan, et al.. B Vitamin and/or ω-3 Fatty Acid Supplementation and Cancer: Ancillary Findings From the Supplementation With Folate, Vitamins B6 and B12, and/or Omega-3 Fatty Acids (SU.FOL.OM3) Randomized Trial. Archives of Internal Medicine -New Series-, 2012, 172 (7), pp.540. ⟨10.1001/archinternmed.2011.1450⟩. ⟨hal-02419963⟩
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