A General Protocol for the Synthesis of H-α-Hydroxyphosphinates Jade Dussart Julia Deschamp* 0 0 0 0 - 0 0 0 2 - 1 9 7 9 - 6 9 1 3 Maelle Monteil Scheme 1 Synthetic pathways to phosphinates and H-phosphinates
Résumé
A general synthetic procedure was developed for H-α-hydroxyphosphinates via Abramov reaction. The present work is a complementary study to hose reported till now. This methodology has the advantage that it can be applied to various aliphatic and (hetero)aromatic substrates. The H-α- hydroxyphosphinates were easily purified and obtained in good to excellent yields in shorter times. A 31P NMR spectroscopy study has shown that only 2 equivalents of a silylating agent were required.
Domaines
Chimie organique
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