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Collection HAL du laboratoire INSERM UMR 1073
The works of our group are mainly dedicated to the study of eating disorders, irritable bowel syndrome (IBS) and inflammatory bowel diseases (IBD). These pathologies share common features of intestinal dysbiosis, inflammation and dysregulation of the gut-brain axis and offer great opportunities for innovative therapeutic strategies (immunonutrition, neurostimulation). Our investigations explore the underlying mechanisms of these diseases from the molecular level to clinical trials. This broad range of research from the bench to the bedside is the result of our research strategy that brings together basic and clinical sciences, in a tight collaboration between laboratory scientists and health professionals. Our dynamic research team has an active research strategy, which also drives the translation of research from the laboratory to patenting and creation of biotech companies entrepreneurship.
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Nos dernières publications
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Lucas Guillo, Guillaume Savoye, Aurélien Amiot, Cyrielle Gilletta, Maria Nachury, et al.. Prevalence of and factors associated with extraintestinal manifestations and their remission in inflammatory bowel disease: the EXTRA prospective study from the GETAID. Clinical and translational gastroenterology, 2023, 14 (12), pp.e00607. ⟨10.14309/ctg.0000000000000607⟩. ⟨hal-04206330⟩
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Pauline Tirelle, Colin Salaün, Alexandre Kauffmann, Christine Bôle-Feysot, Charlène Guérin, et al.. Intestinal Epithelial Toll-like Receptor 4 Deficiency Modifies the Response to the Activity-Based Anorexia Model in a Sex-Dependent Manner: A Preliminary Study. Nutrients, 2022, 14 (17), pp.3607. ⟨10.3390/nu14173607⟩. ⟨hal-03791749⟩
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Ingrid Banovic, Fabrizio Scrima, Isabelle Fornasieri, Laurent Beaugerie, Jérémy Coquart, et al.. Psychometric validation of the French Multidimensional Chronic Asthenia Scale (MCAS) in a sample of 621 patients with chronic fatigue. BMC Psychology, 2023, 11 (1), pp.324. ⟨10.1186/s40359-023-01358-1⟩. ⟨hal-04254402⟩
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Emmanuel Chartier-Kastler, Loïc Le Normand, Alain Ruffion, François Dargent, Raïssa Braguet, et al.. Sacral Neuromodulation with the InterStim™ System for Intractable Lower Urinary Tract Dysfunctions (SOUNDS): Results of Clinical Effectiveness, Quality of Life, Patient-Reported Outcomes and Safety in a French Multicenter Observational Study. European Urology Focus, 2021, 7 (6), pp.1430-1437. ⟨10.1016/j.euf.2020.06.026⟩. ⟨hal-02960057⟩
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Marion Tilmant, Mélanie Serrero, Florian Poullenot, Guillaume Bouguen, Benjamin Pariente, et al.. Endoscopic balloon dilation of colorectal strictures complicating Crohn’s disease: a multicenter study. Clinics and Research in Hepatology and Gastroenterology, 2021, 45 (5), pp.1-6. ⟨10.1016/j.clinre.2020.10.006⟩. ⟨hal-03038308⟩
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Lucia Romo, Joel Ladner, Gayatri Kotbagi, Yannick Morvan, Dalia Saleh, et al.. Attention-deficit hyperactivity disorder and addictions (substance and behavioral): Prevalence and characteristics in a multicenter study in France. Journal of Behavioral Addictions, 2018, 7 (3), pp.743-751. ⟨10.1556/2006.7.2018.58⟩. ⟨hal-02332786⟩
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Mathieu Meleine, Alison Accarie, Lucas Wauters, Joran Toth, Guillaume Gourcerol, et al.. Colonic hypersensitivity and low‐grade inflammation in a spontaneous animal model for functional gastrointestinal disorders. Neurogastroenterology & Motility, 2019, 31 (7), pp.e13614. ⟨10.1111/nmo.13614⟩. ⟨hal-04326848⟩
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Marie-France Vaillant, Lydiane Agier, Caroline Martineau, Manon Philipponneau, Dorothée Romand, et al.. Food intake and weight loss of surviving inpatients in the course of COVID-19 infection: A longitudinal study of the multicenter NutriCoviD30 cohort. Nutrition, 2022, 93, pp.111433. ⟨10.1016/j.nut.2021.111433⟩. ⟨hal-03351419⟩
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Jean Pinson, Jean-Jacques Tuech, Mehdi Ouaissi, Murielle Mathonnet, François Mauvais, et al.. Role of protective stoma after primary anastomosis for generalized peritonitis due to perforated diverticulitis—DIVERTI 2 (a prospective multicenter randomized trial): rationale and design (nct04604730). BMC Surgery, 2022, 22 (1), pp.191. ⟨10.1186/s12893-022-01589-w⟩. ⟨hal-03673254⟩
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Lucy Meunier, Mohamed Belkacemi, George Philippe Pageaux, Sylvie Radenne, Anaïs Vallet-Pichard, et al.. Patients Treated for HCV Infection and Listed for Liver Transplantation in a French Multicenter Study: What Happens at Five Years?. Viruses, 2023, 15 (1), pp.137. ⟨10.3390/v15010137⟩. ⟨hal-03991737⟩
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David Laharie, Arnaud Bourreille, Julien Branche, Matthieu Allez, Yoram Bouhnik, et al.. Evolution of endoscopic lesions in steroid-refractory acute severe ulcerative colitis responding to infliximab or cyclosporine. Clinical Gastroenterology and Hepatology, 2021, 19 (6), pp.1180-1188.e4. ⟨10.1016/j.cgh.2020.08.001⟩. ⟨hal-03551241⟩
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Pauline Tirelle, Jonathan Breton, Alexandre Kauffmann, Wafa Bahlouli, Clément L'Huillier, et al.. Gut microbiota depletion affects nutritional and behavioral responses to activity-based anorexia model in a sex-dependent manner. Clinical Nutrition, 2021, 40 (5), pp.2734-2744. ⟨10.1016/j.clnu.2021.04.014⟩. ⟨hal-03254828⟩
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Maria Nachury, Yoram Bouhnik, Mélanie Serrero, Jerome Filippi, Xavier Roblin, et al.. Patients’ real-world experience with inflammatory bowel disease: A cross-sectional survey in tertiary care centres from the GETAID group. Digestive and Liver Disease, 2021, 53 (4), pp.434-441. ⟨10.1016/j.dld.2020.10.020⟩. ⟨hal-03038260⟩
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Charlène Brochard, Magali Jezequel, Anne Blanchard-Dauphin, Jacques Kerdraon, Brigitte Perrouin-Verbe, et al.. Transanal irrigation is a better choice for bowel dysfunction in adults with spina bifida: a randomized controlled trial. Colorectal Disease, 2023, 25 (6), pp.1267-1276. ⟨10.1111/codi.16518⟩. ⟨hal-04008711⟩
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Sofya Latrache, Chloe Melchior, Charlotte Desprez, Sabrina Sidali, Julien Recton, et al.. Is it necessary to perform a morphological assessment for an esophageal motility disorder? A retrospective descriptive study. Clinics and Research in Hepatology and Gastroenterology, 2021, 45 (6), pp.101633. ⟨10.1016/j.clinre.2021.101633⟩. ⟨hal-03185661⟩